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DTSTAMP:20250806T183535Z
DESCRIPTION:Cell Entrainment in a Mechano-Chemical Model of Collective Cell
  Migration\n\nAndreas Buttenschoen\, UMASS Amherst\n	Tuesday January 16\, 1
 2-1pm\n	Zoom Link: https://mcgill.zoom.us/j/86855481591\n	In Person: 550 She
 rbrooke\, Room 189\n	[Please note the speaker will be presenting in person]
 \n	\n	Abstract: Small GTPases\, such as Rac and Rho\, are well known central
  regulators of cell morphology and motility\, whose dynamics also play a r
 ole in coordinating collective cell migration. Experiments have shown GTPa
 se dynamics to be affected by both chemical and mechanical cues\, but also
  to be spatially and temporally heterogeneous. While progress on understan
 ding GTPase dynamics in single cells has been made\, a major remaining cha
 llenge is to understand the role of GTPase heterogeneity in collective cel
 l migration. Motivated by recent one-dimensional experiments (e.g. micro-c
 hannels) we introduce a one-dimensional modelling framework allowing us to
  integrate cell bio-mechanics\, changes in cell size\, and detailed intra-
 cellular signalling circuits (reaction-diffusion equations).\n\nUsing this
  framework\, we build cell migration models of both loose (mesenchymal) an
 d cohering (epithelial) tissues. We use numerical simulations\, and analys
 is tools\, such as bifurcation and local perturbation analysis\, to provid
 e insights into the regulatory mechanisms coordinating collective cell mig
 ration. We show how feedback from mechanical tension to GTPase activation 
 lead to a variety of dynamics\, including collective and individual cell m
 igration phenotypes.\n
DTSTART:20240116T170000Z
DTEND:20240116T180000Z
SUMMARY:QLS Seminar Series - Andreas Buttenschoen
URL:/qls/channels/event/qls-seminar-series-andreas-but
 tenschoen-353915
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