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DTSTAMP:20250908T054028Z
DESCRIPTION:Evaluation of interactions in clinical and molecular epidemiolo
 gy studies\n\nJaya Satagopan\, Rutgers University\n	Tuesday November 5\, 12
 -1pm\n	McIntyre Medical Building\, room 1034\n\nAbstract: There is a long-s
 tanding interest in the evaluation of interactions between genetic and env
 ironmental factors in molecular epidemiology studies. Recent tumor genomic
 s investigations have inspired evaluations of gene x treatment interaction
 s in clinical studies. The interest in interactions is stimulated by the h
 ope that significant interaction effects identified using statistical mode
 ls can provide insights into optimal screening or preventive interventions
 \, treatment options or patient selection into clinical trials. Interactio
 ns between risk factors are typically examined using a product term of the
  risk factors in statistical models. This talk presents the interpretation
  of such statistical interaction terms to highlight that certain interacti
 ons may be required in statistical models to obtain a good fit to the data
  because of the choice of the scale of the outcome. Therefore\, a pragmati
 c approach to evaluate interactions would be to examine an interaction con
 trast on a clinically desired scale of the outcome. Some useful clinical s
 cales of outcome will be discussed. Data from published cancer epidemiolog
 y studies of bladder cancer and advanced colorectal adenoma and a collabor
 ative study of nevi in children will be used to illustrate interactions fo
 r binary and count outcomes. Since data from large clinical studies of tre
 atment and biomarkers may not always be available\, digitally extracted da
 ta from published phase III clinical trials of metastatic melanoma and met
 astatic colorectal cancer will be used for time-to-event outcomes.\n
DTSTART:20191105T170000Z
DTEND:20191105T180000Z
LOCATION:Room 1034\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1
 Y6\, 3655 promenade Sir William Osler
SUMMARY:QLS Seminar - Jaya Satagopan
URL:/qls/channels/event/qls-seminar-jaya-satagopan-301
 550
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