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DTSTAMP:20250809T193517Z
DESCRIPTION:'Resting-state connectivity biomarkers define neurophysiologica
 l subtypes of depression'\n\nConor Liston (Weill Cornell Medicine)\n	Tuesda
 y November 27\, 12-1pm\n	Montreal Neurological Institute\, Jeanne Timmins A
 mphitheatre\n	\n	Abstract: Biomarkers have transformed modern medicine but r
 emain largely elusive in psychiatry\, partly because there is a weak corre
 spondence between diagnostic labels and their neurobiological substrates. 
 Like other neuropsychiatric disorders\, depression is not a unitary diseas
 e\, but rather a heterogeneous syndrome that encompasses varied\, co-occur
 ring symptoms and divergent responses to treatment. By using functional ma
 gnetic resonance imaging (fMRI) in a large multisite sample (n = 1\,188)\,
  we show here that patients with depression can be subdivided into four ne
 urophysiological subtypes (‘biotypes’) defined by distinct patterns of dys
 functional connectivity in limbic and frontostriatal networks. Clustering 
 patients on this basis enabled the development of diagnostic classifiers (
 biomarkers) with high (82–93%) sensitivity and specificity for depression 
 subtypes in multisite validation (n = 711) and out-of-sample replication (
 n = 477) data sets. These biotypes cannot be differentiated solely on the 
 basis of clinical features\, but they are associated with differing clinic
 al-symptom profiles. They also predict responsiveness to transcranial magn
 etic stimulation therapy (n = 154). Our results define novel subtypes of d
 epression that transcend current diagnostic boundaries and may be useful f
 or identifying the individuals who are most likely to benefit from targete
 d neurostimulation therapies.\n
DTSTART:20181127T170000Z
DTEND:20181127T180000Z
LOCATION:Jeanne Timmins Amphitheatre\, Montreal Neurological Institute\, CA
 \, QC\, Montreal\, H3A 2B4\, 3801 rue University
SUMMARY:Seminar Series in Quantitative Life Sciences and Medicine
URL:/qls/channels/event/seminar-series-quantitative-li
 fe-sciences-and-medicine-291741
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