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UID:20250817T165300EDT-8168uP5Ebd@132.216.98.100
DTSTAMP:20250817T205300Z
DESCRIPTION:Although breast cancer treatment has significantly improved ove
 r the last decade\, developments in the treatment of metastatic tumors lag
  behind\, with 14 women dying of breast cancer every day. A clearer unders
 tanding of the mechanisms controlling cell migration and invasion is neede
 d to identify new therapeutic targets and prevent the spread of primary tu
 mors to distant metastatic sites. In this presentation\, we show that the 
 adapter proteins ShcA (p46/52) and lipoma-preferred partner (LPP) are requ
 ired for TGFβ-induced cell migration and invasion of ErbB2+ breast cancer 
 cells. Both adapter proteins are required for the formation of small\, dyn
 amic adhesions and invadopodia following TGFβ stimulation. Furthermore\, w
 e show that LPP is a mechanosensitive protein in ErbB2+ cells. Using live-
 cell microscopy and PDMS substrates of varying stiffness\, we demonstrate 
 that ErbB2+ cells require LPP expression to modulate migration speed in re
 sponse to substrate stiffness. Finally\, we show that LPP is also an impor
 tant regulator of cell migration\, invasion and metastasis in triple-negat
 ive breast cancer\, an especially aggressive subtype with limited therapeu
 tic options.\n\nThis seminar will be given online via Zoom. Details in att
 ached poster.\n
DTSTART:20210507T150000Z
DTEND:20210507T160000Z
SUMMARY:Online Seminar - ShcA and LPP enhance breast cancer cell migration\
 , invasion and metastasis
URL:/physiology/channels/event/online-seminar-shca-and
 -lpp-enhance-breast-cancer-cell-migration-invasion-and-metastasis-329643
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