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UID:20250819T094407EDT-4644BbVwzi@132.216.98.100
DTSTAMP:20250819T134407Z
DESCRIPTION:In the healthy lung the opportunistic pathogen\, Pseudomonas ae
 ruginosa\, is rapidly eliminated by mucociliary clearance\, a process that
  is dependent on the activity of the CFTR anion channel that\, in concert 
 with a number of other transport proteins\, regulates the volume and compo
 sition of the periciliary surface liquid. This fluid layer is essential to
  enable cilia to clear pathogens from the lungs. However\, in cystic fibro
 sis (CF)\, mutations in the CFTR gene reduce Cl and HCO3 secretion\, there
 by decreasing periciliary surface liquid volume and mucociliary clearance 
 of bacteria. In CF this leads to persistent infection by P. aeruginosa\, w
 hich is the cause of reduced lung function and death in ~95% of CF patient
 s. Studies in our laboratory have shown that P. aeruginosa inhibits both w
 t CFTR Cl secretion and drug rescued Phe508del CFTR Cl secretion and the i
 nflammatory response to infection by secreting outer membrane vesicles tha
 t contain virulence factors and siRNA. By contrast\, airway epithelial cel
 ls secrete extracellular vesicles (EV) containing miRNA that increase the 
 sensitivity of P. aeruginosa to antibiotics\, thereby reducing the infecti
 on. This bi-directionsl communication between the host and pathogen is med
 iated by extracellular vesicles.\n\nThis event is part of the Department o
 f Physiology Friday Seminar Series and is sponsored by the Cystic Fibrosis
  Translational Research Centre.\n\nThis seminar will be given online via Z
 oom. Details in attached poster.\n
DTSTART:20210423T150000Z
DTEND:20210423T160000Z
SUMMARY:Online Seminar - Host-Pathogen Interactions in Cystic Fibrosis: Rol
 e of Extracellular Vesicles and siRNA
URL:/physiology/channels/event/online-seminar-host-pat
 hogen-interactions-cystic-fibrosis-role-extracellular-vesicles-and-sirna-3
 29155
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