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UID:20251121T034116EST-1800NpoHhO@132.216.98.100
DTSTAMP:20251121T084116Z
DESCRIPTION:\nSupported by the generosity of the Killam Trusts\, The Neuro'
 s Killam Seminar Series invites outstanding guest speakers whose research 
 is of interest to the scientific community at The Neuro and 91ºÚÁÏÍø Univers
 ity.\n\n\nRegister Now\n\nTo watch online\, click here\n\nHost: Amir Shmue
 l\n\n\nPushing the boundary on the interpretability of resting-state fMRI
 \n\nJean Chen\n\nProfessor of Medical Biophysics and Biomedical Engineerin
 g at the University of Toronto\n\nAbstract: Resting-state fMRI (rs-fMRI) i
 s a widely used neuroscience tool with well-known capabilities and limitat
 ions. A major challenge is in the physiological interpretation of rs-fMRI 
 measurements\, the lack of which hampers further clinical application. In 
 this talk\, I will present our suite of recent work that uses multi-modal 
 imaging to consolidate the neurometabolic\, neuroelectric and hemodynamic 
 interpretations of common rs-fMRI metrics. To do so\, we developed and app
 lied a biophysical-modeling-based macrovascular correction method to addre
 ss the long-standing issue of macrovascular confounds in the BOLD fMRI sig
 nal. The results show improved physiological relevance of all rs-fMRI metr
 ics after macrovascular correction\, but also reveal that these underpinni
 ngs may in fact differ by sex. This work pushes the boundary of interpreta
 bility for rs-fMRI and fMRI in general.\n\nDr. Chen is Professor of Medica
 l Biophysics and Biomedical Engineering at the University of Toronto\, Sen
 ior Scientist at the Rotman Research Institute\, Baycrest Health Sciences\
 , and Canada Research Chair in Neuroimaging of Aging. She completed her MS
 c in Electrical Engineering at the University of Calgary\, then her PhD in
  Biomedical Engineering at the MNI (supervised by Bruce Pike) and her post
 doc at the Martinos Center for Biomedical Imaging. Her current research re
 volves around the theme of novel methodological development for the study 
 of brain physiology in aging and age-related brain diseases. Her specific 
 interests include studying the neurovascular and electrophysiological mech
 anisms underlying resting-state fMRI\, as well as integrating diffusion MR
 I with functional MRI to study brain aging.\n
DTSTART:20251202T210000Z
DTEND:20251202T220000Z
LOCATION:de Grandpre Communications Centre\, The Neuro
SUMMARY:Killam Seminar Series: Pushing the boundary on the interpretability
  of resting-state fMRI
URL:/neuro/channels/event/killam-seminar-series-pushin
 g-boundary-interpretability-resting-state-fmri-369088
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