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UID:20250926T133407EDT-6474LzH9sl@132.216.98.100
DTSTAMP:20250926T173407Z
DESCRIPTION:The Feindel Brain and Mind Seminar Series will advance the visi
 on of Dr. William Feindel (1918–2014)\, Former Director of the Neuro (1972
 –1984)\, to constantly bridge the clinical and research realms. The talks 
 will highlight the latest advances and discoveries in neuropsychology\, co
 gnitive neuroscience\, and neuroimaging.\n\nSpeakers will include scientis
 ts from across The Neuro\, as well as colleagues and collaborators locally
  and from around the world. The series is intended to provide a virtual fo
 rum for scientists and trainees to continue to foster interdisciplinary ex
 changes on the mechanisms\, diagnosis and treatment of brain and cognitive
  disorders.\n\n\nRegister for In-Person\n\nUnable to attend in person? Joi
 n us virtually here.\n\nHost: Alain Dagher\n\n\nVascular Risk Factors\, Co
 rtical Atrophy\, and Dementia: Genes\, Cells\, and Molecules\n\nAbstract: 
 Zdenka Pausova will present research investigating the role of vascular ri
 sk factors in the etiology of cortical atrophy\, Alzheimer’s disease\, and
  related dementia. Her work combines genetics and in silico transcriptomic
 s with brain magnetic resonance imaging (MRI) in large-scale\, population-
 based cohorts. This clinical research is complemented by studies in mice\,
  which employ parallel brain MRI\, serial two-photon tomography\, and sing
 le-cell transcriptomics to provide cellular- and process-level insights.\n
 \nZdenka Pausova\n\nProfessor\, Department of Pediatrics\, University of M
 ontreal\n\n\n\nFor the past 25 years\, Zdenka Pausova’s laboratory has stu
 died the causes and consequences of obesity throughout the lifespan\, with
  recent work focusing on obesity as a negative vascular risk factor for br
 ain health. With a background in medicine\, endocrinology\, and genetics\,
  she integrates knowledge from these fields with the latest technological 
 advances. Her team combines multi-omics—genetics\, epigenetics\, transcrip
 tomics\, and metabolomics—with detailed phenotyping\, including brain and 
 body magnetic resonance imaging\, in large-scale\, population-based cohort
 s. Parallel studies in mouse models complement this research\, enabling ex
 ploration of causality and insights into cellular and molecular mechanisms
 .\n\nDr. Pausova has published over 230 papers in peer-reviewed journals a
 nd holds an H-index of 77. She co-directs the Saguenay Youth Study (SYS)\,
  a longitudinal study of 2\,000 adolescents and their parents investigatin
 g cardiometabolic and brain health. She contributes her expertise and SYS 
 data to numerous international collaborative consortia\, including NeuroCH
 ARGE and ENIGMA. Within these collaborations\, she has recently led two ma
 jor projects: (i) metabolomic profiling of cerebral small vessel disease i
 n over 9\,000 participants (Circulation\, 2022\, PMID: 35050683)\, and (ii
 ) genetic studies of the relationships between cerebral small vessel disea
 se\, cortical atrophy\, and dementia in more than 50\,000 participants\, c
 omplemented by replication in 500\,000 individuals (Nature Communications\
 , 2024\, PMID: 39496600). She has also leveraged other large-scale dataset
 s\, including the UK Biobank\, where her team demonstrated that cortical t
 issue loss in type 2 diabetes begins early—during the prediabetic stage—an
 d may involve dysregulated excitatory neuron signalling (Diabetes Care\, 2
 023\, PMID: 37824790).\n
DTSTART:20250929T170000Z
DTEND:20250929T180000Z
LOCATION:Jeanne Timmins Amphitheatre\, The Neuro
SUMMARY:Feindel Brain and Mind Seminar Series: Vascular Risk Factors\, Cort
 ical Atrophy\, and Dementia: Genes\, Cells\, and Molecules
URL:/neuro/channels/event/feindel-brain-and-mind-semin
 ar-series-vascular-risk-factors-cortical-atrophy-and-dementia-genes-367520
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