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UID:20250512T193736EDT-1990HuUOU3@132.216.98.100
DTSTAMP:20250512T233736Z
DESCRIPTION:\nSupported by the generosity of the Killam Trusts\, The Neuro'
 s Killam Seminar Series invites outstanding guest speakers whose research 
 is of interest to the scientific community at The Neuro and 91ºÚÁÏÍø Univers
 ity.\n\n\nRegister Now\n\nTo watch online\, click here\n\nHost: Edward Rut
 hazer\n\n\nPosttranslational Palmitoylation in Brain Development and Disea
 se\n\nShernaz Bamji\n\nProfessor\, Department of Cellular and Physiologica
 l Sciences\, University of British Columbia \n\nAbstract: Palmitoylation i
 s the most common post-translational lipid modification in the brain. This
  presentation focusses on the role of the palmitoylating enzyme\, ZDHHC9\,
  which has been strongly associated with X-linked intellectual disability 
 (XLID). Patients with ZDHHC9 loss-of-function mutations exhibit reduced co
 rpus callosum volume and impaired white matter integrity. Our work demonst
 rates that ablation of Zdhhc9 in mice substantially impairs the maturation
  of oligodendrocytes and results in a concomitant decrease in the density 
 of myelinated axons. Ultrastructural analysis of the remaining myelinated 
 axons in the corpus callosum revealed further disruptions in myelin integr
 ity. Transcriptomic and proteomic analyses reveal decreased expression of 
 genes and proteins crucial for lipid metabolism\, cholesterol synthesis\, 
 and myelin compaction. Notably\, Zdhhc9 knockout also disrupts axon outgro
 wth and pathfinding in the corpus callosum. These findings unveil a previo
 usly overlooked role for ZDHHC9 in governing oligodendrocyte maturation an
 d myelinogenesis\, and offers mechanistic insights into white matter volum
 e deficits in patients with ZDHHC9 mutations.\n\n\n\nShernaz Bamji is a Pr
 ofessor in the Department of Cellular and Physiological Sciences at the Un
 iversity of British Columbia (UBC)\, where she also serves as co-Director 
 of the Djavad Mowafaghian Center for Brain Health. She is a past President
 -elect of the Canadian Association for Neurosciences. Dr. Bamji completed 
 her PhD under the mentorship of Dr. Freda Miller at the Montreal Neurologi
 cal Institute (91ºÚÁÏÍø)\, investigating the role of BDNF in neur
 onal survival and death. She then moved to San Francisco and pursued postd
 octoral research with Dr. Louis Reichardt at the University of California\
 , San Francisco (UCSF)\, examining how cadherin adhesion molecules influen
 ce synapse formation and plasticity. Dr. Bamji’s research centers on the m
 olecular and cellular mechanisms that govern brain development and neurona
 l connectivity. Her findings have deepened our understanding of the proces
 ses that underlie learning and memory\, as well as how these processes are
  disrupted in disease.\n
DTSTART:20250422T200000Z
DTEND:20250422T210000Z
LOCATION:de Grandpre Communications Centre\, The Neuro
SUMMARY:Killam Seminar Series: Posttranslational Palmitoylation in Brain De
 velopment and Disease
URL:/neuro/channels/event/killam-seminar-series-posttr
 anslational-palmitoylation-brain-development-and-disease-364892
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