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DESCRIPTION:Richard Bethlehem presents: Brain chart for the human lifespan
 \n\nRegistration available here.\n\nSpeaker: Richard Bethlehem\n\nDirector
  of Neuroimaging\, Autism Research Centre\, University of Cambridge\, Unit
 ed Kingdom\n\nAbstract: Over the past few decades\, neuroimaging has becom
 e a ubiquitous tool in basic research and clinical studies of the human br
 ain. However\, no reference standards currently exist to quantify individu
 al differences in neuroimaging metrics over time\, in contrast to growth c
 harts for anthropometric traits such as height and weight. Here\, we built
  an interactive resource to benchmark brain morphology\, www.brainchart.io
 \, derived from any current or future sample of magnetic resonance imaging
  (MRI) data. With the goal of basing these reference charts on the largest
  and most inclusive dataset available\, we aggregated 123\,984 MRI scans f
 rom 101\,457 participants aged from 115 days post-conception through 100 p
 ostnatal years\, across more than 100 primary research studies. Cerebrum t
 issue volumes and other global or regional MRI metrics were quantified by 
 centile scores\, relative to non-linear trajectories of brain structural c
 hanges\, and rates of change\, over the lifespan. Brain charts identified 
 previously unreported neurodevelopmental milestones\; showed high stabilit
 y of individual centile scores over longitudinal assessments\; and demonst
 rated robustness to technical and methodological differences between prima
 ry studies. Centile scores showed increased heritability compared to non-c
 entiled MRI phenotypes\, and provided a standardised measure of atypical b
 rain structure that revealed patterns of neuroanatomical variation across 
 neurological and psychiatric disorders. In sum\, brain charts are an essen
 tial first step towards robust quantification of individual deviations fro
 m normative trajectories in multiple\, commonly-used neuroimaging phenotyp
 es. Our collaborative study proves the principle that brain charts are ach
 ievable on a global scale over the entire lifespan\, and applicable to ana
 lysis of diverse developmental and clinical effects on human brain structu
 re.\n\nBio: Richard Bethlehem is a British Academy Post-Doctoral Fellow wo
 rking on developmental neuroimaging of autism and related conditions. His 
 research focuses on three broad fields:\n\n1. Investigating the trajectori
 es of brain development in typical and atypical neurodevelopment.\n	2. Inte
 grating multi-modal imaging and genetic information into parsing neurodeve
 lopmental trajectories.\n	3. Influence of neuromodulatory hormones on brain
  function in developmental psychopathology\n\nRichard specializes in brain
  imaging\, genomics and computational neuroscience applied to large cohort
 s of neuroimaging and transcriptomic datasets. Within Cambridge he activel
 y collaborates with the Brain Mapping Unit and outside Cambridge maintains
  active collaborations with UCLA (Geschwind & Gandal labs)\, 91ºÚÁÏÍø/MNI (M
 ICA-lab led by Dr. Boris Bernhardt) and ICM Paris (Dr. Daniel Margulies).
 \n\nKey Publications:\n	– Romero-Garcia\, R.\, Warrier\, V.\, Bullmore\, E.
 T.\, Baron-Cohen\, S. & Bethlehem\, R.A.I. (2018). Synaptic and transcript
 ionally downregulated genes are associated with cortical thickness differe
 nces in children with autism. Molecular Psychiatry\, link to paper\n	– Hong
 \, S.J.\, Vos De Wael\, R.\, Bethlehem\, R.A.I.\, Lariviere\, S.\, Paquola
 \, C.\, Valk\, S.L.\, Di Martino\, A.\, Milham\, M.P.\, Margulies\, D.S.\,
  Smallwood\, J. & Bernhardt B.C. (2019). Atypical functional connectome hi
 erarchy in autism. Nature Communications 10\, Article number: 1022 (Epub a
 head of print) link to paper\n	– Bethlehem\, R.A.I.\, van Honk\, J.\, Auyeu
 ng\, B. & Baron-Cohen S. (2013). Oxytocin\, brain physiology\, and functio
 nal connectivity: a review of intranasal oxytocin fMRI studies. Psychoneur
 oendocrinology\, 38\, 7\, pp. 962-974\n\n\nThe Feindel Virtual Brain and M
 ind (VBM) Seminar Series will advance the vision of Dr. William Feindel (1
 918–2014)\, Former Director of the Neuro (1972–1984)\, to constantly bridg
 e the clinical and research realms. The talks will highlight the latest ad
 vances and discoveries in neuropsychology\, cognitive neuroscience\, and n
 euroimaging.\n\nSpeakers will include scientists from across The Neuro\, a
 s well as colleagues and collaborators locally and from around the world. 
 The series is intended to provide a virtual forum for scientists and train
 ees to continue to foster interdisciplinary exchanges on the mechanisms\, 
 diagnosis and treatment of brain and cognitive disorders.\n
DTSTART:20220119T210000Z
DTEND:20220119T220000Z
SUMMARY:Feindel Virtual Brain and Mind Lecture Series: Brain chart for the 
 human lifespan
URL:/neuro/channels/event/feindel-virtual-brain-and-mi
 nd-lecture-series-brain-chart-human-lifespan-336474
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