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UID:20250820T014956EDT-4088uiEPlT@132.216.98.100
DTSTAMP:20250820T054956Z
DESCRIPTION:Pablo Paez will present\, 'Modulation of oligodendrocyte develo
 pment and myelination by voltage-gated Ca++ channels'.\n\nRegistration ava
 ilable here. \n\nSpeaker: Pablo Paez\, PhD\n	Associate Professor\, Institut
 e for Myelin and Glia Exploration\, Department of Pharmacology and Toxicol
 ogy\, School of Medicine and Biomedical Sciences\, University at Buffalo\,
  SUNY\n\nAbstract: The oligodendrocyte generates CNS myelin\, which is ess
 ential for normal nervous system function. Thus\, investigating the regula
 tory and signaling mechanisms that control its differentiation and the pro
 duction of myelin is relevant to our understanding of brain development an
 d of adult pathologies such as multiple sclerosis. We have recently establ
 ished that the activity of voltage-gated Ca++ channels is crucial for the 
 adequate migration\, proliferation and maturation of oligodendrocyte proge
 nitor cells (OPCs). Furthermore\, we have found that voltage-gated Ca++ ch
 annels that function in synaptic communication between neurons also mediat
 e synaptic signaling between neurons and OPCs. Thus\, we hypothesize that 
 voltage-gated Ca++ channels are central components of OPC-neuronal synapse
 s and are the principal ion channels mediating activity-dependent myelinat
 ion.\n\n\nSupported by the generosity of the Killam Trusts \, The Neuro’s 
 Killam Seminar series hosts outstanding guest speakers whose research is o
 f interest to the scientific community at The Neuro and 91ºÚÁÏÍø.
 \n
DTSTART:20220208T210000Z
DTEND:20220208T220000Z
SUMMARY:Killam Seminar Series presents 'Modulation of oligodendrocyte devel
 opment and myelination by voltage-gated Ca++ channels'
URL:/neuro/channels/event/killam-seminar-series-presen
 ts-modulation-oligodendrocyte-development-and-myelination-voltage-gated-33
 5299
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