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UID:20260602T074410EDT-0202UOrPvt@132.216.98.100
DTSTAMP:20260602T114410Z
DESCRIPTION:Title: Modeling the Joint Distribution of Compositional Microbi
 ome Data.\n\nAbstract\n\nMicrobiome epidemiology demands generative models
  of community profiles for study design considerations such as power analy
 sis. We developed SparseDOSSA\, a statistical model that parameterizes mic
 robial communities and can be used to simulate new\, realistic profiles to
  inform study designs. Our model connects zero-inflated marginals with a G
 aussian copula\, and has an additional renormalization component. As such\
 , it uniquely satisfies common compositional\, zero-inflation\, and intera
 ction properties of microbiome data. We demonstrate that SparseDOSSA accur
 ately models human-associated microbiomes\, and can generate realistic syn
 thetic communities with prescribed population and ecological structures. W
 e provide an open-source implementation for SparseDOSSA\, which can be use
 d in practice for power analysis and method benchmarking to inform microbi
 ome study designs.\n\n \n\nSpeaker bio\n\nSiyuan is an Assistant Professor
  at the Department of Biostatistics at the Vanderbilt University Medical C
 enter. His work focuses on statistical methods for modern molecular epidem
 iology applications. His methods research includes batch correction and me
 ta-analysis\, dimension reduction\, and high-dimensional modeling and cond
 itional testing. His application areas include the healthy and dysbiotic m
 icrobiome\, cancer transcriptomics\, and spatially resolved imaging proteo
 mics. He obtained his Ph.D. in biostatistics from Harvard T.H. Chan School
  of Public Health and had postdoctoral training at the University of Penns
 ylvania.\n\nZoom\n\n \n
DTSTART:20230322T193000Z
DTEND:20230322T203000Z
LOCATION:Room 1104\, 91ºÚÁÏÍø College 2001\, CA\, QC\, Montreal\, H3A 1G1\, 2
 001\, avenue 91ºÚÁÏÍø College
SUMMARY:Siyuan Ma (Vanderbilt University Medical Center)
URL:/mathstat/channels/event/siyuan-ma-vanderbilt-univ
 ersity-medical-center-347185
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