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UID:20260621T220049EDT-8322XDoLNC@132.216.98.100
DTSTAMP:20260622T020049Z
DESCRIPTION:Titile: Uncovering Hidden Connections in Hematological Regulato
 ry Networks.\n\nAbstract: The process of producing all of the body's blood
  cells is robustly regulated by an extensive network of cytokines. General
 ly speaking\, the principal (and often secondary\, tertiary etc.) role of 
 each of these molecules has been identified. However\, given the fundament
 al role of the hematopoietic system and its constituents to organismal hea
 lth\, many cytokines perform ancillary functions within network structures
  that remain to be elucidated. Oftentimes\, hematopoietic dysregulation in
  the form of blood pathologies can help to identify dynamical relationship
 s that we are unable to discern in healthy individuals. Cyclic thrombocyto
 penia is one such dynamical disease. We analyzed time series data from an 
 individual with CTP using standard Fourier and statistical approaches (per
 iodogram and correlation analysis) in addition to convergent cross mapping
  (Sugihara et al.\, Detecting causality in complex ecosystems. Science\, 2
 012) to infer causal relationships amongst 64 cytokines (and their gene ex
 pressions)\, uncovering a plethora of novel relationships. These results f
 urther refine our understanding of the many networks that support the prod
 uction of blood cells and immunological responses\, and may help to identi
 fy novel therapies and drug targets.\n
DTSTART:20190320T200000Z
DTEND:20190320T210000Z
LOCATION:Room 4186\, CA\, Pav. André-Aisenstadt
SUMMARY:Ski Krieger\, Harvard University
URL:/mathstat/channels/event/ski-krieger-harvard-unive
 rsity-295506
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