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UID:20260629T024121EDT-3915XuUvlP@132.216.98.100
DTSTAMP:20260629T064121Z
DESCRIPTION:You are invited to attend a special seminar hosted by the Insti
 tute of Parasitology.\n\nDr. David Langlais completed his Ph. D. with hono
 urs in Molecular Biology in 2011 at Université de Montreal\, and is curren
 tly pursuing postdoctoral research in Dr. Philippe Gros laboratory at McGi
 ll University. He is now studying the role of the transcription factors IR
 F8 and IRF1 in the interferon gamma (IFNg) response to infection. He is al
 so evaluating the role of these transcriptional networks in human tubercul
 osis and malaria infections\, still two of the most deadly diseases world-
 wide. This work may pave the way toward the identification of novel therap
 eutic targets against these infections\n\nCerebral malaria (CM) is a sever
 e complication of Plasmodium falciparum infection\, claiming a young life 
 every 2 minutes. The pathophysiology is poorly understood\, but clearly im
 plicates an overwhelming neuroinflammatory response in non-immune individu
 als. By investigating the possible causative mechanisms\, we have shown th
 at genetic inactivation of IRF8 and IRF1 transcription factors confers pro
 tection against CM. Furthermore\, through functional genomics studies\, we
  highlighted the pivotal role of their transcriptional program not only in
  CM pathology\, but also in chronic inflammatory diseases. Altogether\, I 
 will describe how functional genomics is leading to the identification of 
 new potential therapeutic targets against pathological inflammation and to
  novel treatments\, a critical issue for CM patients.\n
DTSTART:20171024T153000Z
DTEND:20171024T170000Z
LOCATION:Room CC1-163\, Centennial Centre\, CA\, QC\, St Anne de Bellevue\,
  H9X 3V9\, 21111 Lakeshore Road
SUMMARY:Functional genomics of host responses: Precision drug target discov
 ery
URL:/macdonald/channels/event/functional-genomics-host
 -responses-precision-drug-target-discovery-270394
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