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UID:20260628T150444EDT-3174CSHKiZ@132.216.98.100
DTSTAMP:20260628T190444Z
DESCRIPTION:PhD Oral Defense of Sonia Inès Edayé\, Institute of Parasitolog
 y\nPlasmodium falciparum is the deadly protozoan parasite responsible for 
 malaria. Malaria is one of the most important infectious diseases that has
  been raging for millennia and affecting almost half of the world’s popula
 tion. The treatment regimen that was based on quinoline drugs such as chlo
 roquine (CQ)\, was efficient for decades. Nowadays\, the use of this class
  of drugs is doomed to failure due to the emergence of quinoline-resistant
  parasites. Today\, artemisinin-based combination therapies (ACTs) are the
  first-line drugs for uncomplicated falciparum malaria treatment. ACTs imp
 rove the cure rate of malaria and thus are seen as efficient treatment aga
 inst uncomplicated forms of the disease. Despite their efficiency\, these 
 drugs are currently facing the development of resistance. PfCRT and PfMDR1
 \, which are membrane transporters\, have been shown to be involved in mal
 aria parasites drug resistance. To tackle the inefficiency of existing dru
 gs in regard to the development of resistance\, alternative therapies must
  be discovered. In this thesis\, antimalarial activity of novel potential 
 drugs against P. falciparum is assessed and the interaction of these drugs
  with PfCRT and PfMDR1 is determined. Furthermore\, because many ABC trans
 porter genes play a key role in drug resistance\, the characterization of 
 an ABC transporter member of the ABCG family in Plasmodium is addressed an
 d its role in drug resistance investigated.\n\nEveryone in the 91ºÚÁÏÍø comm
 unity is welcome to attend a PhD oral defense. Please join us in celebrati
 ng the accomplishments of our PhD candidates.
DTSTART:20150227T200000Z
DTEND:20150227T200000Z
LOCATION:P-117\, Parasitology Building\, CA\, QC\, St Anne de Bellevue\, H9
 X 3V9\, 21111 Lakeshore Road
SUMMARY:PhD Oral Defense: Characterization of Plasmodium falciparum Resista
 nce to Novel Drugs: A Study of PfCRT\, PfMDR1 and PfABCG Mediated Drug Res
 istance
URL:/macdonald/channels/event/phd-oral-defense-charact
 erization-plasmodium-falciparum-resistance-novel-drugs-study-pfcrt-pfmdr1-
 243049
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