BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4//
BEGIN:VEVENT
UID:20260628T121710EDT-6892WVBdk4@132.216.98.100
DTSTAMP:20260628T161710Z
DESCRIPTION:PhD Oral Defense of Pablo Godoy Rosas\, Institute of Parasitolo
 gy.\nHaemonchus contortus is a parasitic nematode distributed all around t
 he world where ruminants graze and decreases animal production. In order t
 o control this veterinary helminth\, anthelmintic drugs are still the main
  strategy in veterinary medicine. One particular anthelmintic class is the
  macrocyclic lactones (MLs)\, which has remarkable efficacy against endo a
 nd ectoparasites in animal and human health. Unfortunately\, due to the co
 ntinuous use of the MLs against parasitic nematodes\, including H. contort
 us\, has led to drug resistance\, that limits their use. In H. contortus\,
  one of the resistance mechanisms involved could be the over expression of
  P-glycoproteins (PGPs) and possibly other nematode transporters\, which b
 elong to the ATP-Binding-Cassette (ABC) transporter protein family. The ac
 tivity of the ABC transporters is the extrusion of many unrelated compound
 s across the cell membrane. In the host\, these plasma membrane proteins a
 re expressed in different organs and tissues influencing the bioavailabili
 ty and pharmacokinetics of different substrates including the MLs. In H. c
 ontortus and other nematodes\, some ABC transporters have shown a consiste
 nt link with ML resistance. In addition\, studies characterizing the inter
 action between mammalian ABC transporters with ML such as avermectins\, ha
 ve established a strong interaction between these compounds and PGP activi
 ty\, transporting these drugs and contributing to their elimination.\nThe 
 goal of this project was the characterization of some H. contortus P-glyco
 proteins (Hco-PGP-2\, Hco-PGP-9.1 and Hco-PGP-16) and their interaction wi
 th MLs such as avermectins and moxidectin in order to elucidate if these t
 ransporters may play a role in ML resistance in this parasite.\n\nEveryone
  in the 91ºÚÁÏÍø community is welcome to attend a PhD oral defense. Please j
 oin us in celebrating the accomplishments of our PhD candidates.
DTSTART:20150226T184500Z
DTEND:20150226T184500Z
LOCATION:P-117\, Parasitology Building\, CA\, QC\, St Anne de Bellevue\, H9
 X 3V9\, 21111 Lakeshore Road
SUMMARY:PhD Oral Defense: Haemonchus contortus ABC Transporters Linked to M
 acrocyclic Lactone Resistance
URL:/macdonald/channels/event/phd-oral-defense-haemonc
 hus-contortus-abc-transporters-linked-macrocyclic-lactone-resistance-24241
 7
END:VEVENT
END:VCALENDAR