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UID:20260630T020640EDT-2311NzntH3@132.216.98.100
DTSTAMP:20260630T060640Z
DESCRIPTION:PhD Oral Defense of Shoaib Ashraf\, Institute of Parasitology 
 \nABSTRACT\n\nIvermectin (IVM) is a macrocyclic lactone (ML) endectocide. 
 It acts on the glutamate gated chloride channels and causes paralysis and 
 death of nematode parasites. It is used in veterinary and human health as 
 well as in agriculture. Haemonchus contortus (H. contortus) is a very path
 ogenic nematode of livestock. Attempts to control it with anthelmintic pha
 rmaceuticals\, such as IVM\, has rapidly led to the development of drug re
 sistance against most of the known anthelmintics. Caenorrhabditis elegans 
 (C. elegans) is a free living nematode that can be easily grown and cultiv
 ated on culture plates. Both of these nematodes have proven excellent mode
 ls to study drug resistance mechanisms. Observations that IVM selects on β
 -tubulin in some nematodes\, including H. contortus led the candidate to s
 tudy recombinant H. contortus β-and α-tubulins\, and microtubules formed w
 hen these tubulins polymerize.\n\nEveryone in the 91ºÚÁÏÍø community is welc
 ome to attend a PhD oral defense. Please join us in celebrating the accomp
 lishments of our PhD candidates.
DTSTART:20150220T190000Z
DTEND:20150220T190000Z
LOCATION:P-117\, Parasitology Building\, CA\, QC\, St Anne de Bellevue\, H9
 X 3V9\, 21111 Lakeshore Road
SUMMARY:PhD Oral Defense: Tubulin and Ivermectin Pharmacology in the Parasi
 tic Nematode Haemonchus contortus
URL:/macdonald/channels/event/phd-oral-defense-tubulin
 -and-ivermectin-pharmacology-parasitic-nematode-haemonchus-contortus-24240
 4
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