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UID:20260629T144740EDT-7802ibDnOs@132.216.98.100
DTSTAMP:20260629T184740Z
DESCRIPTION:PhD Oral Defense of Kevin MacDonald\, Institute of Parasitology
 \nSchistosomiasis is a debilitating neglected tropical disease that affect
 s hundreds of millions of people in developing tropical and subtropical ar
 eas of the world. As a long-term chronic infection\, schistosomiasis cause
 s significant annual mortality and morbidity\, as well as economic losses.
  The causative agents of the disease are flatworms of the genus Schistosom
 a\, which are vectored by several snail intermediate hosts into humans. On
 ce inside the human host\, schistosomes undergo a complex migratory and de
 velopmental period before maturing into adult worms. A key regulator of th
 is process is the parasite nervous system\, which controls a variety of es
 sential biological functions in both larval and adult schistosomes. Signal
  transduction in the nervous system results from the interaction between n
 eurotransmitters and their cognate receptors. In vertebrates\, acetylcholi
 ne (ACh) is the quintessential excitatory neurotransmitter of the neuromus
 cular system. In schistosomes\, on the other hand\, there is evidence that
  it plays an inhibitory role in parasite motility. This divergence from th
 e vertebrate mode of action suggests that the receptors responsible for me
 diating this activity may serve as good chemotherapeutic targets. To date\
 , no schistosome cholinergic receptor has been characterized at the molecu
 lar level or linked to neuromuscular inhibition. In the present work\, we 
 demonstrate the existence of a novel family of schistosome cholinergic rec
 eptors that modulate inhibitory neuromuscular responses.\n\nEveryone in th
 e 91ºÚÁÏÍø community is welcome to attend a PhD oral defense. Please join us
  in celebrating the accomplishments of our PhD candidates.
DTSTART:20140424T174500Z
DTEND:20140424T174500Z
LOCATION:P-117\, Parasitology Building\, CA\, QC\, St Anne de Bellevue\, H9
 X 3V9\, 21111 Lakeshore Road
SUMMARY:PhD Oral Defense: Exploring the Role of Cholinergic Receptors in Sc
 histosoma mansoni Motor Function
URL:/macdonald/channels/event/phd-oral-defense-explori
 ng-role-cholinergic-receptors-schistosoma-mansoni-motor-function-235346
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