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UID:20250928T140248EDT-9668GmujSa@132.216.98.100
DTSTAMP:20250928T180248Z
DESCRIPTION:You are cordially invited to attend the seminar of Dr. Louis-Ph
 ilippe Leroux\, a candidate for the tenure-track position of Assistant Pro
 fessor in One Health Against Pathogens in the Institute of Parasitology.\n
 \nTitle: From innate immunity to a One Health perspective: Understanding t
 he molecular mechanisms to combat parasitic diseases\n\nParasitic diseases
  are caused by a broad range of evolutionary diverse organisms and affect 
 both animal and human populations worldwide as well as the environment. Un
 fortunately\, parasites often receive less attention to the extent that ma
 ny diseases caused by these organisms are absent from the global health ag
 enda despite being among the most prevalent. In order to fight these patho
 gens\, it is imperative to understand how they subvert immune responses to
  persist within their hosts. The apicomplexan Toxoplasma gondii and the he
 lminths from the Trichuris genus have proven to be useful models to study 
 these complex biological processes. Our work with these organisms has demo
 nstrated that the modulation of innate immune responses involves complex t
 ranscriptional\, translational\, and posttranslational networks in part in
 fluenced by parasite-derived virulence factors. Building upon these studie
 s\, unraveling the regulatory mechanisms\, through integrated multiomics a
 nd immunophenotyping approaches\, may help identify common pathways dysreg
 ulated during both infections and other diseased states such as inflammato
 ry disorders and pave the way to novel therapies and\, by extension\, stre
 ngthen global health.\n\nAbout the speaker\n\nLouis-Philippe Leroux\n\nCan
 didate for the Assistant Professor Position One Health Against Pathogens\n
 \nI obtained my Ph.D. at the Institute of Parasitology under the supervisi
 on of Dr. Florence Dzierszinski. My thesis focused on the dysregulation of
  MHC-II antigen presentation by the Toxoplasma gondii. I then undertook my
  first postdoctoral training in Dr. Armando Jardim's laboratory at 91ºÚÁÏÍø.
  Our work focused on the excreted-secreted molecules from the pig whipworm
  Trichuris suis.\n\nI later joined Dr. Maritza Jaramillo's laboratory at t
 he INRS-CAFSB for a second postdoctoral training. I spearheaded projects t
 hat led to the first published translatomes of macrophages infected by par
 asites (T. gondii and Leishmania donovani). Recently\, we have initiated d
 rug screening projects to investigate the anti-parasitic potential of synt
 hetic rocaglate compounds\, which target mRNA translation. In addition to 
 my academic research\, I have worked as a Principal Scientist at CellCarta
 \, a contract research organization (CRO)\, where I supervised over 20 stu
 dies sponsored by pharmaceutical and biotechnology companies. Furthermore\
 , I am a cofounder of the Canadian Parasitology Network (CPN)\, a pan-Cana
 dian network of researchers and trainees\, and helm its various activities
 . Now\, I wish to establish my laboratory to study the role of central nod
 es of regulation that dictate innate immune polarization and functions in 
 response to parasitic diseases and their virulence factors.\n\n \n
DTSTART:20250626T160000Z
DTEND:20250626T170000Z
LOCATION:3-048\, Raymond Building\, CA\, QC\, St Anne de Bellevue\, H9X 3V9
 \, 21111 Lakeshore Road
SUMMARY:Recruitment Seminar: Assistant Professor in One Health Against Path
 ogens (OHAP) in the Institute of Parasitology
URL:/macdonald/channels/event/recruitment-seminar-assi
 stant-professor-one-health-against-pathogens-ohap-institute-parasitology-3
 65747
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