BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20250714T052218EDT-0103mPvO41@132.216.98.100 DTSTAMP:20250714T092218Z DESCRIPTION:Marie Davidian\, PhD\n\nJ. Stuart Hunter Distinguished Professo r\n Department of Statistics |\n North Carolina State University\n\nWHEN: Fr iday\, January 24\, 2025\, from 3:30 to 4:30 p.m. \n WHERE: Virtual Seminar | Zoom\n NOTE: Marie Davidian will be presenting virtually\n\nAbstract\n\n The sequential multiple assignment randomized trial (SMART) is the gold st andard study design for the evaluation of multistage treatment regimes\, w hich comprise sequential decision rules that recommend treatments for a pa tient at each of a series of decision points based on their evolving chara cteristics. A common goal is to compare the set of so-called embedded regi mes represented in the design on the basis of a primary outcome of interes t. In the study of chronic diseases and disorders\, this outcome is often a time to an event\, and a goal is to compare the distributions of the tim e-to-event outcome associated with each regime in the set. We present a ge neral statistical framework in which we develop a logrank-type test for co mparison of the survival distributions associated with regimes within a sp ecified set based on the data from a SMART with an arbitrary number of sta ges that allows incorporation of covariate information to enhance efficien cy and can also be used with data from an observational study. The framewo rk provides clarification of the assumptions required to yield a principle d test procedure\, and the proposed test subsumes or offers an improved al ternative to existing methods. The methods are applied to a SMART in patie nts with acute promyelocytic leukemia.\n\nSpeaker Bio\n\nMarie Davidian is a J. Stuart Hunter Distinguished Professor of Statistics at North Carolin a State University (NC State) and Adjunct Professor of Biostatistics and B ioinformatics at Duke University. Her research interests include methodolo gy for the design and analysis of clinical trials and observational studie s\, for causal inference and dynamic treatment regimes\, for analysis of m issing and mismeasured data\, and for longitudinal data analysis. Marie is a Fellow of the American Statistical Association (ASA)\, Institute of Mat hematical Statistics (IMS)\, and the American Association for the Advancem ent of Science\, and an elected member of the International Statistical In stitute. Marie has received several awards and recognitions\, including th e ASA Award for Outstanding Statistical Application (1993)\, the Janet L. Norwood Award for Outstanding Achievement by a Woman in the Statistical Sc ience\, the Committee of Presidents of Statistical Societies (COPSS) Flore nce Nightingale David Award\, the COPSS George W. Snedecor Award\, the ASA Founders Award\, and the Marvin Zelen Leadership Award in Statistical Sci ence from the Harvard T. H. Chan School of Public Health\; as well as hono rary life memberships in the IMS and International Biometric Society. She has been Coordinating and Executive Editor of the journal Biometrics\, ser ved on several US Food and Drug Administration Advisory Committees\, and s erved on several US National Institutes of Health (NIH) grant review panel s\, including as Chair of the Biostatistical Methods and Research Design S tudy Section. Marie has published over 135 refereed papers and several boo ks. She has supervised over 30 PhD students. For two decades\, Marie was P rogram Director for the Summer Institute for Biostatistics (SIBS)\, which introduced talented US undergraduates to careers in biostatistics and enco uraged them to pursue graduate training\; and an NIH predoctoral training grant\, which placed PhD students at NC State and Duke with cardiovascular disease research projects at Duke Clinical Research Institute\, providing them hands-on collaborative experience in health sciences research.\n DTSTART:20250124T203000Z DTEND:20250124T213000Z SUMMARY:A Generalized Logrank-type Test for Comparison of Treatment Regimes in Sequential Multiple Assignment Randomized Trials URL:/epi-biostat-occh/channels/event/generalized-logra nk-type-test-comparison-treatment-regimes-sequential-multiple-assignment-r andomized-362148 END:VEVENT END:VCALENDAR