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BEGIN:VEVENT
UID:20251120T173237EST-9097ejUtSi@132.216.98.100
DTSTAMP:20251120T223237Z
DESCRIPTION:Abstract:\n\nIn 2021\, while developing a differential mobility
  spectrometry (DMS) method for separating anti-arrhythmic drugs\, we obser
 ved distinct behavioural differences between Verapamil\, a chiral tertiary
  amine\, and its demethylated amine metabolite\, Norverapamil – Verapamil’
 s ionogram exhibited two baseline-resolved features\, whereas Norverapamil
 ’s showed only one. We found that Verapamil’s behaviour arose from protona
 tion-induced chirality (PIC) of its tertiary amine during electrospray ion
 ization\, which produced diastereomers that could be separated in the gas 
 phase via DMS.\n\nOver the last few years\, we have stepped through the lo
 oking glass and into a chiral wonderland\, where we are now developing new
  multi-dimensional chiral liquid chromatography\, ion mobility spectrometr
 y\, and mass spectrometry methods to analyze chiral compounds. Recently\, 
 we used our new techniques to study bioaccumulation of drug enantiomers in
  fish near wastewater treatment facilities\, and to reveal the phenomenon 
 of protonation-induced pseudo-chirality (PIpC) of pseudo-asymmetric tertia
 ry amines. In this seminar\, I’ll introduce some of our new analytical met
 hods and I’ll describe some recent applications in this space.\n\n \n\nBio
 :\n\nScott Hopkins a professor of physical chemistry at the University of 
 Waterloo and Project Lead for WaterFEL\, Canada’s new free electron laser 
 laboratory. He is a global leader in physical and analytical chemistry\, a
 nd applications of his research program include the characterization of tr
 ace contaminants in environmental and biological samples\, as well as the 
 identification and investigation of new phenomena in molecular systems. Pr
 of. Hopkins has published more than 100 articles\, has authored two books\
 , and has filed seven patents. He has been recognized with several nationa
 l awards\, including the PerkinElmer Award for Spectroscopy and Analytical
  Sciences and the Keith Laidler Award of the Canadian Society for Chemistr
 y. Scott has given more than 60 invited lectures and more than 20 intervie
 ws in the popular media. His water analysis program screens water quality 
 for more than 3 million Canadians and he has recently begun working with a
  team of researchers at the University of Toronto and several Toronto hosp
 itals to develop new AI-driven tools for intra-operative cancer diagnostic
 s.\n
DTSTART:20251118T180000Z
DTEND:20251118T193000Z
LOCATION:OM 10\, Maass Chemistry Building\, CA\, QC\, Montreal\, H3A 0B8\, 
 801 rue Sherbrooke Ouest
SUMMARY:Chemical Society Seminar: Scott Hopkins- Beyond the Column: How Ion
  Mobility Adds a New Dimension to Chiral LC–MS Analysis
URL:/chemistry/channels/event/chemical-society-seminar
 -scott-hopkins-beyond-column-how-ion-mobility-adds-new-dimension-chiral-lc
 -368894
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