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UID:20250904T050952EDT-4875RbkHFK@132.216.98.100
DTSTAMP:20250904T090952Z
DESCRIPTION:Abstract:\n\n \n\nOur research team is interested in understand
 ing biomolecule-electrode interfaces for measuring concentrations of targe
 t molecules in complex matrices (whole blood\, saliva\, etc.). Measuring i
 nsulin and glucose in a closed-loop fashion\, for example\, could diminish
  the incidence of low-glycemic events. Bedside monitoring of narrow therap
 eutic drugs like vancomycin or associated biomarkers can likewise allow fo
 r efficient intervention and deaths prevention. These examples illustrate 
 how valuable having access to a measuring platform capable of rapidly dete
 rmining concentrations of several molecules at once could transform health
 care.\n\nOur efforts to develop this measuring platform so far have largel
 y been in functionalizing electrodes with nucleic acids\, like aptamers\, 
 for their use as biosensors. Through the modification of the nucleic acids
  with redox reporter molecules\, we can electrochemically interrogate thei
 r binding state so that we can rapidly (< 5 min) and continuously monitor 
 target concentrations in various matrices. Thanks to the relatively inexpe
 nsive and easily miniaturizable electronics analogous to the home glucomet
 er\, we envision that these biosensors can provide a detailed molecular pr
 ofile conveniently and rapidly at the point-of-care.\n\n \n\nIn this prese
 ntation\, I will be sharing the team’s results on: \n\n \n\n\n	Portable and
  wearable devices for electrochemical interrogation of biosensors.\n	Host-g
 uest electrochemical biosensors for reagentless measurements.\n	Aptamer-bas
 ed electrochemical biosensors\, from their biophysical characterization us
 ing NMR\, calorimetry and computational tools to their multiplexed ability
  for continuous and real-time measurements directly in undiluted whole blo
 od and human saliva.\n\n\n \n\nWe hope these new tools will prove useful i
 n transitioning from a population-based medicine towards a personalized fu
 ture in which each individual is empowered to make decisions on their heal
 th.\n\n \n\nBio:\n\nDauphin-Ducharme P. is a bioanalytical electrochemist 
 who started (Jan 2020) his independent research group as an assistant prof
 essor in the Chemistry Department at Université de Sherbrooke. He received
  his PhD training under the guidance of Prof. Janine Mauzeroll where he sp
 ecialized in scanning probe techniques to study corrosion of light alloys.
  Through a collaboration with Prof. Hanadi Sleiman where his passion for D
 NA electrochemistry started\, he decided to pursue a postdoctoral stay at 
 University of California at Santa Barbara with Prof. Kevin Plaxco where he
  contributed to developing new electrochemical DNA-based biosensors. Build
 ing on his electrochemistry\, biosensors\, scanning probe techniques and m
 aterials chemistry expertise cited over 2000x in 40 peer-reviewed publicat
 ions and 4 patents\, his research team now studies electrode-biomolecule i
 nterfaces to develop new biosensors that deploy in complex matrices like b
 lood or saliva. His most important contribution has been the development o
 f new aptamer-based electrochemical biosensors for detection of molecules 
 in the body where one is currently undergoing human clinical trial for fut
 ure commercialization.\n
DTSTART:20240917T170000Z
DTEND:20240917T183000Z
LOCATION:OM 10\, Maass Chemistry Building\, CA\, QC\, Montreal\, H3A 0B8\, 
 801 rue Sherbrooke Ouest
SUMMARY:Chemical Society Seminar:Philippe Dauphin Ducharme- Nucleic Acids E
 lectrochemical Biosensors for Point-of-care Measurements
URL:/chemistry/channels/event/chemical-society-seminar
 philippe-dauphin-ducharme-nucleic-acids-electrochemical-biosensors-point-3
 58411
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