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UID:20250816T204506EDT-83522A0HPu@132.216.98.100
DTSTAMP:20250817T004506Z
DESCRIPTION:Abstract:\n\nReactions which can manipulate the connectivity of
  the molecular skeleton are underexplored as tools for late-stage function
 alization\, in part because their implementation has been hindered by thei
 r often nonintuitive retrosynthetic logic. This presentation will cover se
 lected transformations discovered in our laboratory which address this cha
 llenge by enabling single-atom changes to aliphatic and aromatic systems t
 hrough the insertion and deletion of single heavy atoms (C\,N\,O\, etc.)\,
  as well as more complex manipulations leveraging combinations of these el
 ementary transformations. Our approach to this problem is modality-agnosti
 c\, drawing from a wide range of reactive species and synthetic discipline
 s (organometallic chemistry\, reagent design\, photochemistry). Applicatio
 ns to late-stage functionalization and diversification of complex pharmace
 utically relevant compounds as well as unique opportunities for synthesis 
 will be presented alongside mechanistic findings.\n\n \n\nBio:\n\nMark was
  born and raised in Cleveland\, OH as the oldest of three children in a Ru
 ssian-Jewish immigrant family. In 2012\, he earned a B.S. in chemistry fro
 m the University of Rochester in Rochester\, NY\, conducting undergraduate
  research with Professor Alison J. Frontier on an oxidative variant of the
  Nazarov cyclization. Through participation in the DAAD RISE program\, Mar
 k also spent the summer of 2010 conducting research with Henning Hopf at T
 U Braunschweig on the synthesis of strained hydrocarbons. After graduation
 \, he joined the laboratory of Professor F. Dean Toste at the University o
 f California\, Berkeley. There\, he studied the chemistry of the Au(I)/Au(
 III) redox couple in several contexts\, including supramolecular catalysis
  and fluorine-18 radiosynthesis. After earning his Ph.D. in 2017\, Mark jo
 ined the laboratory of Professor Eric N. Jacobsen as an NIH Postdoctoral F
 ellow at Harvard University where his research focused on enantioselective
  fluorination reactions with chiral organoiodane catalysts. In 2019\, Mark
  joined the University of Chicago as an assistant professor of chemistry a
 nd was promoted to associate professor with tenure in 2022. His research i
 nterests include the development of synthetic methodology and study of the
 ir mechanisms.\n
DTSTART:20230124T180000Z
DTEND:20230124T193000Z
LOCATION:Room 10\, Maass Chemistry Building\, CA\, QC\, Montreal\, H3A 0B8\
 , 801 rue Sherbrooke Ouest
SUMMARY:Chemical Society Seminar: Mark Levin - Single Atom Logic for Skelet
 al Editing
URL:/chemistry/channels/event/chemical-society-seminar
 -mark-levin-single-atom-logic-skeletal-editing-340126
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