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VERSION:2.0
PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4//
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UID:20250904T163959EDT-2230WuJSku@132.216.98.100
DTSTAMP:20250904T203959Z
DESCRIPTION:Abstract:\n\nThe Cytochromes P450 are heme-thiolate enzymes tha
 t carry out selective oxyfunctionalization of a wide range of substrates C
 -H bonds using molecular dioxygen and two reducing equivalents. Recent eff
 orts have focused on the use of light-harvesting units to trigger P450 act
 ivity upon visible light excitation. Our laboratory has taken advantage of
  Ru(II)-diimine complexes and their unique excited properties to harness t
 he P450 synthetic potential. The covalent attachment of these photosensiti
 zers to non-native single cysteine residues has enabled rapid electron inj
 ections into the heme domain of several bacterial P450 enzymes leading to 
 high photocatalytic activity and coupling efficiency. The crystal structur
 e of the most efficient hybrid enzyme reveals that the photosensitizer is 
 ideally positioned to deliver electrons to the heme active site utilizing 
 the natural electron transfer pathway. A combination of rational and direc
 ted evolution approaches are currently employed to optimize the biocatalys
 t photocatalytic activity and expand the scope of the light-driven P450 ac
 tivity. In addition\, we recently sought to capitalize on the photoredox p
 roperties of these inorganic complexes combined with the P450 biocatalysis
  to develop novel chemoenzymatic approaches including selective light-driv
 en trifluoromethylation/ oxyfunctionalization of several substituted arene
 s.\n\nBio:\n\nDr. Lionel Cheruzel grew up in Cannes\, South of France\, be
 fore moving to the United States in 1999 to pursue his graduate studies. U
 pon completion of his Ph.D. at the University of Louisville\, KY\, he join
 ed as a postdoctoral fellow the laboratory of Prof. Harry B. Gray at the C
 alifornia Institute of Technology in Pasadena\, CA. In Fall 2009\, he star
 ted as an assistant professor in the Department of Chemistry at San Jose S
 tate University. He was promoted to full professor in August 2019. He is t
 he recipient of the 2013 Journal of Biological Chemistry/Herbert Tabor You
 ng Investigator Award and the 2019 Henry Dreyfus Teacher Scholar Award.\n
DTSTART:20191029T170000Z
DTEND:20191029T183000Z
LOCATION:Room 10\, Maass Chemistry Building\, CA\, QC\, Montreal\, H3A 0B8\
 , 801 rue Sherbrooke Ouest
SUMMARY:CCVC: Lionel Cheruzel - Light-driven P450 biocatalysts featuring Ru
 (II)-polypyridyl complexes 
URL:/chemistry/channels/event/ccvc-lionel-cheruzel-lig
 ht-driven-p450-biocatalysts-featuring-ruii-polypyridyl-complexes-299601
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