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UID:20260713T075629EDT-6014ZVkbOe@132.216.98.100
DTSTAMP:20260713T115629Z
DESCRIPTION:DEPARTMENT OF ANATOMY AND CELL BIOLOGY SEMINAR\nSERIES\n“Pertur
 bation of Wnt Signaling Pathways and Vascular\nPathobiology”\nDr. Marlene 
 Rabinovitch\nSTANFORD UNIVERSITY\nWEDNESDAY\, MAY 25th\n11:30AM 12:30PM\nM
 1 LECTURE HALL\nDr. Marlene Rabinovitch is a Dwight and Vera Dunlevie Prof
 essor\nof  Pediatric Cardiology\, and Research Director of the Vera\nMoult
 on Wall Center for Pulmonary Vascular Disease\, at Stanford\nUniversity Sc
 hool of Medicine. She is the 2010 recipient of the\nLouis and Artur Lucian
  Award for Research in Circulatory\nDiseases.\n\n'Our research program has
  focused for three decades on trying to\nbetter\nunderstand the mechanisms
  leading to pulmonary arterial\nhypertension (PAH) with the long-range vie
 w that we might better\ntreat this devastating condition. We focused on un
 derstanding the\nlink between the genetics and the cell pathobiology and d
 iscovered\nrelationships between degradation of elastin by an endogenous\n
 elastase\, loss of pre-capillary vessels\, and proliferation of\nvascular 
 cells in larger pre- and intra-acinar pulmonary\narteries.\nWe showed that
  suppression of elastase activity could reverse\nexperimentally-induced PA
 H. We recently discovered molecular\npathways downstream of the gene that 
 is mutant in familial PAH\,\ni.e.\, bone morphogenetic protein receptor (B
 MPR)II that explain how\nactivation of this receptor protects EC from apop
 tosis and\nresulting precapillary loss and also attenuates PA SMC\nprolife
 ration in response to growth factors. Major work from our\nlab using human
  cells and genetically modified mice is eludicating\ninteractions between 
 BMPRII-PPARg mediated gene regulation and Wnt\nsignaling.”\n
DTSTART:20110525T153000Z
DTEND:20110525T163000Z
SUMMARY:Special seminar: Dr. Marlene Rabinovitch
URL:/channels/event/special-seminar-dr-marlene-rabinov
 itch-174380
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