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UID:20260628T082448EDT-94003OogF0@132.216.98.100
DTSTAMP:20260628T122448Z
DESCRIPTION: \nDr. Laurent Sabbagh\n\nAssistant Professor\nResearch Center 
 - Maisonneuve-Rosemont Hospital\nDepartment of Microbiology and Immunology
 \nUniversity of Montreal\n'Signalling lymphocyte survival through TRAF1'\n
  \nAbstract\n \nTumour necrosis factor receptors (TNFRs) are a family of\n
 receptors involved in transmitting survival and death signals in\nlymphocy
 tes. The balance between survival and death signalling\nplays a critical r
 ole in determining the outcome of an immune\nresponse and the subsequent s
 urvival and maintenance of memory T\ncells. TNFR-associated factors (TRAFs
 ) are a family of adaptor\nproteins involved in linking TNFR family member
 s to downstream\nsignalling pathways. TRAF1 is unique among TRAFs in that 
 it lacks a\nRING finger domain present in all other TRAFs and has the most
 \nrestricted expression pattern\; found almost exclusively in\nlymphocytes
 \, dendritic cells and certain epithelia. Overexpression\nof TRAF1 in many
  tumours of B cell origin is consistent with a\nsurvival function. I will 
 discuss the role of TRAF1 in the survival\nof CD8 memory T cells. In addit
 ion\, the dependence of the 4-1BB\nreceptor\, a member of the TNFR family\
 , on TRAF1 in mediating\nsurvival of CD8 T cells will be discussed. Using 
 a systems biology\napproach novel TRAF1 binding partners have been identif
 ied to\nunderstand TRAF1-dependent-signalling pathways downstream of TNFRs
 \nin CD8 T cells. Understanding signalling events downstream of TNFRs\nand
  the contribution of TRAF1 will allow the design of new\ntherapies to incr
 ease the output of CD8 memory T cells\, enhancing\nnot only cancer therapy
  regimens but infectious disease treatments\nas well.\n
DTSTART:20101125T160000Z
DTEND:20101125T160000Z
LOCATION:Duff Medical Building\, CA\, QC\, Montreal\, H3A 2B4\, 3775 rue Un
 iversity
SUMMARY:Guest Speaker Seminar - Dr. Laurent Sabbagh
URL:/channels/event/guest-speaker-seminar-dr-laurent-s
 abbagh-169630
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