BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4//
BEGIN:VEVENT
UID:20260711T103009EDT-5905UhEnLJ@132.216.98.100
DTSTAMP:20260711T143009Z
DESCRIPTION:Dr. Dao Nguyen\n\nAssistant Professor\nDepartment of Medicine\n
 91ºÚÁÏÍø\n'The role of starvation responses in Pseudomonas aerugi
 nosa\nantibiotic tolerance'\n \nAbstract\n \nThe successful treatment of b
 acterial infections requires\nbacteria to be eradicated. When host defense
 s are compromised\,\nbacterial killing by antibiotics is critical. Bacteri
 a can develop\nphenotypic multi-drug tolerance without harboring any inher
 itable\nmechanism of resistance\, and the mechanisms of tolerance remain\n
 largely unknown. Bacteria become tolerant under several growth\nconditions
 \, most notably when depleted for nutrients. We are\ninvestigating whether
  starvation confers tolerance by inducing a\nspecific response\, the strin
 gent response\, mediated by (p)ppGpp.\nNutrient starvation and induction o
 f the stringent response may\nalso be the common mechanism underlying the 
 marked tolerance\nobserved in both stationary phase and biofilm growth. We
  studied\nthe opportunistic pathogen Pseudomonas aeruginosa to investigate
 \nwhether disruption of the stringent response impaired antibiotic\ntolera
 nce in-vitro and in-vivo\, and how (p)ppGpp mediated\ntolerance. The strin
 gent response\, a non-essential highly conserved\nbacterial stress respons
 e\, may be an attractive and novel\ntherapeutic target to enhance the effi
 cacy of antibiotic treatments\nagainst tolerant infections\, such as Pseud
 omonas aeruginosa biofilm\ninfections.\n
DTSTART:20101118T160000Z
DTEND:20101118T160000Z
LOCATION:Duff Medical Building\, CA\, QC\, Montreal\, H3A 2B4\, 3775 rue Un
 iversity
SUMMARY:Guest Speaker Seminar - Dr. Dao Nguyen - Thursday\, Nov. 18\, 2010
URL:/channels/event/guest-speaker-seminar-dr-dao-nguye
 n-thursday-nov-18-2010-169522
END:VEVENT
END:VCALENDAR