BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4//
BEGIN:VEVENT
UID:20260601T145207EDT-03321Wk2UF@132.216.98.100
DTSTAMP:20260601T185207Z
DESCRIPTION:Dr. Richard Wozniak\nProfessor\nDepartment of Cell Biology\nUni
 versity of Alberta\n“Sculpting the chromatin landscape: a role for nuclear
  pore\ncomplex assembly in chromatin structure”\n \nIn eukaryotic cells\, 
 the trafficking of macromolecules across\nthe nuclear envelope\, either in
 to or out of the nucleus\, is\ncontrolled by nuclear pore complexes (NPCs)
 .  NPCs are massive\nstructures\, ~65 MDa in mass and consisting of ~30 di
 fferent\nproteins (termed nucleoporins) present in multiple copies. In\nad
 dition to controlling transport\, a growing body of literature has\nlead t
 o the conclusion that NPCs also interact with chromatin and\ncontribute to
  the regulation of gene expression.  The\nmechanistic basis for these inte
 ractions\, however\, remains\nunclear.  In recent studies\, we have uncove
 red genetic and\nphysical links between Nup170p\, a nucleoporin critical f
 or the\nassembly of NPCs\, and proteins functioning in chromatin remodelin
 g.\nOn the basis these and other observations to be discussed\, we\nhypoth
 esize that Nup170p functions as a key component in the\nformation of the N
 PC and as a platform for the recruitment of\nchromatin remodeling complexe
 s\, in particular the RSC (Remodels\nStructure of Chromatin) complex\, to 
 sites of NPC formation. \nHere\, we predict these proteins function in NPC
  assembly and in the\nformation\, and/or maintenance\, of chromatin domain
 s in the vicinity\nof the NPC\, including those functioning in the transcr
 iptional\nrepression of subtelomeric genes.\n \n \nMakio\, T.\, L. H. Stan
 ton\, C. C. Lin\, D. S. Goldfarb\, K. Weis\,\nand R. W. Wozniak. 2009. \nT
 he \nnucleoporins \nNup170p and Nup157p are essential for nuclear pore com
 plex\nassembly. J Cell Biol. 185:459-73.\n \nKöhler\, A. and E. Hurt. 2010
 . Gene regulation\nby nucleoporins\nand links to\ncancer. Mol Cell. 38:6-1
 5.\n
DTSTART:20100514T170000Z
DTEND:20100514T170000Z
LOCATION:McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1Y6\, 3655 pr
 omenade Sir William Osler
SUMMARY:Biochemistry Seminar Dr. Richard Wozniak
URL:/channels/event/biochemistry-seminar-dr-richard-wo
 zniak-163323
END:VEVENT
END:VCALENDAR