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UID:20260628T202209EDT-4867O7uEht@132.216.98.100
DTSTAMP:20260629T002209Z
DESCRIPTION:Dr. Marc Gingras\nInterdisciplinary Center on Nanoscience of Ma
 rseille\n(CINaM)\,\nCNRS UPR n° 3118\, and Aix-Marseille University\, Fran
 ce\nA growing interest in carbohydrate chemistry and glycobiology\nappeare
 d in the last years\, because of some major discoveries\ninvolving carbohy
 drates and their roles played in fundamental\nbiochemical processes (cance
 r\, inflammation\, AIDS\, cell-cell\nadhesion\, etc.). In view of those fi
 ndings\, carbohydrate-lectin\nrecognition represents an important field of
  study. For better\nunderstanding those interactions\, selective inhibitio
 ns and a\ncontrol of lectin assemblies are often necessary. As a consequen
 ce\,\nsome multivalent glycosylated asterisk ligands (dendrimers) having\n
 a dual function\, as biological probes and as inhibitors\, were\ndeveloppe
 d. We synthesized a novel class of colored\, luminescent\,\nUV- and electr
 ochemically responsive glycosylated asterisks to\ninvestigate the so-calle
 d “carbohydrate cluster effects” (or\nmultivalency effects). They are effe
 ctive inhibitors against\nseveral lectins\, near the nanomolar scale. Seve
 ral biophysical\ntechniques were used to characterize those interactions a
 nd\nassemblies over time: surface plasmon resonance (SPR)\,\nturbidimetry\
 , dynamic light scatering (DLS)\, ITC\, crystallization\,\netc.. The lecti
 n models were from Pseudomonas aeruginosa (PA-1-L)\,\nBurkholderia cenocep
 acia (BcLA) or Con A. Novel biosensors or a\nhigher class of fluorophores 
 will be sought\, as well as a new mode\nof biofilms inhibition (especially
  for PA colonies and the\nassociated lungs infection in patients suffering
  from cystic\nfibrosis).\n
DTSTART:20091026T160000Z
DTEND:20091026T160000Z
LOCATION:McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1Y6\, 3655 pr
 omenade Sir William Osler
SUMMARY:Chemical Biology Lecture Series: Dr. Marc Gingras
URL:/channels/event/chemical-biology-lecture-series-dr
 -marc-gingras-109888
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